The Quisby is located in a historic building that once house the Audubon Hotel. The Audubon Hotel opened for business at a time when the Mississippi River was the busiest commercial corridor in the country and New Orleans was a hub of commerce, banking, and transportation. The hotel catered to the boat captains and deckhands that worked the river, transporting agricultural and manufactured goods to cities along the Mississippi and as far north as Chicago. At different times, the downstairs area served as the site of two well-known New Orleans establishments, the original Bamboo Dance Club and, more recently, the raucous Audubon Club. The building underwent a complete restoration in 2016 that preserved its historic character while adding modern amenities.
The restored building remains as a representation of the design and scale of the Central City Historic District. The architectural detail is expressed mostly in the main facade of the building which exhibits elements of the craftsmen style. It is one of the few examples in the district of a three-story structure from the historic period as most were only built to a single story.
The double casement windows, storefront, and terra cotta roof all add to the significance of this architectural and cultural asset of the Central City Neighborhood.